Endocrine Abstracts

In humans and other mammalian species, follicular development is a complicated process. The pool of resting primordial follicles serves as the source of developing follicles and fertilizable ova for the entire length of female reproductive life. In recent years, molecular mechanisms underlying follicular activation and development have become more evident, mainly through the use of genetically modified mouse models. Recently reported mutant mouse models have shown that a syner...

In humans and other mammalian species, the pool of resting primordial follicles serves as the source of developing follicles and fertilizable ova for the entire length of female reproductive life. In recent years, molecular mechanisms underlying follicular activation have become more evident, mainly through the use of genetically-modified mouse models. As hypothesized in the 1990s, the pool of primordial follicles is now known to be maintained in a dormant state by various for...